Recombinant HMGB1 Monoclonal Antibody

SKU: AN301554L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:HMGB1

Target Synonym:SBP;HMGB;High Mobility Group Protein;High mobility group protein B;HMG;HMG-1;HMG1;HMG3;SBP-1;HMGB1;Amphoterin;High Mobility Group Protein 1;High mobility group protein B1;High mobility group protein 1 (HMG-1);High mobility group protein 1;high mobility group protein B1;high-mobility group box 1;HMG1;HMG-1;HMG1DKFZp686A04236;HMG3;HMGB1;SBP-1;Chromosomal protein;DKFZp686A04236;High mobility group 1;High mobility group box 1;high-mobility group (nonhistone chromosomal) protein 1;HMGB 1;nonhistone;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;FCM;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A253

UNIProt ID:P09429

Accession:

Background:Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.

Concentration:1 mg/mL

Immunogen:Recombinant human HMGB1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:200-1:1000;FCM 1:50-1:100;IP 1:25

Calculated MW:25 kDa

ObservedMW:25 kDa