Recombinant HIP2/LIG Monoclonal Antibody

SKU: AN301704L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:HIP2/LIG

Target Synonym:HIP;UBC;UBE2K;E2-25K;HIP2;HYPG;LIG;UBC1;HIP-2;Huntingtin-Interacting Protein 2;Ubiquitin Carrier Protein;Ubiquitin-Conjugating Enzyme E2 K;Ubiquitin-Conjugating Enzyme E2(25K);Ubiquitin-Conjugating Enzyme E2-25 kDa;Ubiquitin-Conjugating Enzyme E2-25K;Ubiquitin-Protein Ligase

Research Areas:Neuroscience;Epigenetics and Nuclear Signaling;Cell Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A412

UNIProt ID:P61086

Accession:

Background:Huntingtin-interacting protein 2 (HIP2/LIG), is a E2 ubiquitin-conjugating enzyme, which accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, HIP2/LIG catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, while it does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Moreover, HIP2/LIG mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins.

Concentration:1 mg/mL

Immunogen:Recombinant human HIP2/LIG fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000

Calculated MW:22 kDa

ObservedMW:22 kDa