Recombinant Glypican-3 Monoclonal Antibody

SKU: AN301865L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Glypican-3

Target Synonym:MXR;GPC;UNQ;PRO;CDw;ADAM;Protein FOAP;Secreted glypican;Glypican proteoglycan;Sialic acid-binding Ig-like lectin;C20orf;OCI;GPC3;DGSX;GTR2-2;MXR7;OCI-5;SDYS;SGB;SGBS;SGBS1;glypican-3;CDw329;Glypican 3;Glypican proteoglycan 3;Glypican-3 [Precursor];GTR2 2;Heparan sulphate proteoglycan;Intestinal protein OCI 5;Intestinal protein OCI-5;OCI 5;Protein FOAP-9;Secreted glypican-3;Sialic acid-binding Ig-like lectin 9;SIGLEC9;Siglec-9;ADAM33;C20orf153;UNQ873;PRO1891;OCI5

Research Areas:Stem Cells;Signal Transduction;Cancer;Developmental Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A577

UNIProt ID:P51654

Accession:

Background:Glypican 3 belongs to Glypicans (GPCs), a family of glycosylphosphatidylinositol (GPI)-anchored heparan sulphate proteoglycans (HSPGs) that may play a role in the control of cell division and growth regulation. In mammals, there are six GPCs (GPC1 to GPC6), all of which have a similar core-protein size of approx. 60 kDa and the clustering of glycosaminoglycan attachment site near the C-terminus. They are tethered to the cell surface by GPI linkages, which can be cleaved by endogenous phospholipases, thus releasing the protein. Glypican 3 (GPC3) is highly expressed in many tissues during development and plays an important role in the regulation of embryonic growth. Loss-of-function mutations of GPC3 result in the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and Gpc-3 null mice display developmental overgrowth. In hepatocellular carcinoma (HCC), the overexpression of glypican 3 has been demonstrated to be a reliable diagnostic indicator.

Concentration:1 mg/mL

Immunogen:Recombinant human Glypican-3 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:2000-1:10000;IHC 1:100-1:500;IF 1:50

Calculated MW:70, 40 kDa

ObservedMW:15, 70 kDa