Recombinant GAD-65/67 Monoclonal Antibody

SKU: AN301129L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:GAD-65/67

Target Synonym:GAD;GAD2;GAD65;65 kDa glutamic acid decarboxylase;DCE 2;DCE2;GAD 2;GAD 65;GAD-2;GAD-65;Glutamate decarboxylase 2;Glutamate decarboxylase 2 (pancreas);Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa);Glutamate Decarboxylase 65;Glutamate decarboxylase 65 kDa isoform;Glutamic Acid Decarboxylase 2;Glutamic Acid Decarboxylase 65;MGC161605;MGC161607;GAD-65/67

Research Areas:Neuroscience;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12G12

UNIProt ID:Q05329;Q99259

Accession:

Background:GAD1(glutamate decarboxylase 1) Homo sapiens This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human GAD-65/67 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:10000-1:50000

Calculated MW:65 kDa,67 kDa

ObservedMW:65 kDa,67 kDa