Recombinant Cynomolgus CD40/TNFRSF5/CD40L receptor Protein (His Tag)

SKU: PKSQ050045

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Immune Checkpoint Proteins

Abbreviation: CD40;TNFRSF5

Target Synonym: B-Cell Surface Antigen CD40;Bp50;CD40;CD40L Receptor;CDw40;TNFRSF5;Tumor Necrosis Factor Receptor Superfamily member 5

Research Areas:

Conjugation:

Target Species: Cynomolgus macaques

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: G7PG38

Accession: G7PG38

Background: CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.

Concentration:

Activity: Not validated for activity

Sequence: Glu21-Arg193

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 20.2 kDa

ObservedMW: 28-30 kDa