Recombinant CD25 Monoclonal Antibody

SKU: AN301472L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:CD25

Target Synonym:IMD;IDDM;IL2RA;CD25;IDDM10;IL2R;IMD41;TCGFR;p55;IL-2 receptor subunit alpha;IL-2R subunit alpha;IL2-RA;IL-2-RA;IL-2Rα;Interleukin-2 receptor subunit alpha;TAC antigen;Tac;p55;IL-2Rαalpha chain;CD25 antigen;IL 2 receptor alpha subunit;IL2 RA;Interleukin 2 receptor;Interleukin 2 receptor alpha;Interleukin 2 receptor alpha chain;t-cell growth factor receptor

Research Areas:Immunology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:IF;FCM

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A167

UNIProt ID:P01589

Accession:

Background:The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.

Concentration:1 mg/mL

Immunogen:Recombinant human CD25 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:IF 1:50;FCM 1:50-1:100

Calculated MW:

ObservedMW: