Recombinant ARG1/Arginase 1 Monoclonal Antibody

SKU: AN300403P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:ARG1

Target Synonym:ARGI;ARG;ARG1;arginase-1;A I;Al;ARG 1;ARGI1;Arginase;Arginase 1;Arginase I;Arginase liver;Arginase type I;Arginase1;liver;Liver Arginase;Liver type arginase;Liver-type arginase;Type I arginase;A I;Al;ARG 1;arg1;ARGI1;Arginase 1;Arginase liver;Arginase type I;Arginase;liver;Arginase-1;Arginase1;Liver type arginase;Liver-type arginase;Type I arginase;Arginase

Research Areas:Signal Transduction;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC-P;FCM;ICC/IF

Isotype:IgG

Clonality:Monoclonal

Clone NO.:9D10

UNIProt ID:P05089

Accession:

Background:Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion.

Concentration:1 mg/mL

Immunogen:Recombinant Human ARG1/Arginase 1 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;IHC-P 1:500-1:2500;ICC/IF 1:20-1:100;FCM 1:100-1:500

Calculated MW:35 kDa

ObservedMW:40 kDa