Recombinant AIFM1 Monoclonal Antibody

SKU: AN300718L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:AIFM1

Target Synonym:CMTX;DFNX;PDCD;AIFM;Programmed Cell Death Protein;COXPD;AIF;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;AIFM1;Apoptosis-Inducing Factor 1 Mitochondrial;Programmed Cell Death Protein 8;Apoptosis inducing factor;Apoptosis inducing factor 1;Apoptosis-inducing factor 1;axonal;axonal motor-sensory;Harlequin;mAIF;MGC111425;MGC5706;mitochondrial;mitochondrion associated;motor-sensory with deafness and mental retardation (Cowchock syndrome);Neuropathy;PDCD 8;Programmed Cell Death 8;Programmed cell death 8 (apoptosis inducing factor);Programmed cell death 8 isoform 1;Programmed cell death 8 isoform 2;Programmed cell death 8 isoform 3;Programmed cell death protein 8 mitochondrial;Programmed cell death protein 8 mitochondrial precursor;Striatal apoptosis inducing factor;with deafness and mental retardation

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12G13

UNIProt ID:O95831

Accession:

Background:This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human AIFM1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:67 kDa

ObservedMW:67 kDa