Recombinant 53BP1 Monoclonal Antibody

SKU: AN301369L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:53BP1

Target Synonym:53BP;TDRD;tumor protein p53 binding protein;p53BP;TP53BP;TP53BP1;53BP1;TDRD30;TP53;p202;p53BP1;tumor protein p53 binding protein 1;53BP1;p202;p53BP1;TDRD30;TP53;tumor protein p53 binding protein 1

Research Areas:Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5F5

UNIProt ID:Q12888

Accession:

Background:This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human 53BP1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;IHC 1:200-1:1000

Calculated MW:214 kDa

ObservedMW:450 kDa