RBP4 Monoclonal Antibody

SKU: AN200017P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:RBP4

Target Synonym:RET;PRO;Retinol-binding protein;MCOPCB;RBP4;MCOPCB10;RDCCAS;RBP-4;RET4;PRBP;RBP;Retinol-binding protein 4;Plasma retinol-binding protein;Cleaved into Plasma retinol-binding protein;Plasma retinol-binding protein 1-181;Plasma retinol-binding protein 1-179;Plasma retinol-binding protein(1-176);PRO2222

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling;Cardiovascular;Metabolism

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:IHC-P

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:7F15

UNIProt ID:P02753

Accession:

Background:Retinol (also known as vitamin A) is unstable and insoluble in the aqueous solution. However, retinol becomes quite stable and soluble in plasma due to its tight interaction with retinol-binding protein 4 (RBP4), also known as plasma retinol-binding protein. A prototypic member of the lipocalin superfamily, RBP4 has a beta -barrel structure with a well-defined cavity. It is secreted from the liver, a process requiring the availability of retinol. RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. The retinol-RBP4-TTR complex prevents the loss of RBP4 by filtration through the kidney and increases the stability of the retinol-RBP4 complex. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision.

Concentration:1 mg/mL

Immunogen:Recombinant Human RBP4 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:50-1:200;

Calculated MW:

ObservedMW: