RBBP6 Antibody, HRP conjugated - Cat. #: CSB-PA768776LB01HU

SKU: CSB-PA768776LB01HU

Size :50ug

Clone Number:

Aliases:DKFZp686P0638 antibody; DKFZp761B2423 antibody; E3 ubiquitin-protein ligase RBBP6 antibody; MY038 antibody; P2P R antibody; P2PR antibody; p53 associated cellular protein of testis antibody; p53-associated cellular protein of testis antibody; p53-associated cellular protein, testis-derived antibody; PACT antibody; Proliferation potential related protein antibody; Proliferation potential-related protein antibody; Protein P2P R antibody; Protein P2P-R antibody; Protein P2PR antibody; Protein RBQ 1 antibody; Protein RBQ1 antibody; RB binding protein 6, ubiquitin ligase antibody; RB binding Q protein 1 antibody; RBBP 6 antibody; Rbbp6 antibody; RBBP6_HUMAN antibody; RBQ 1 antibody; RBQ-1 antibody; RBQ1 antibody; Retinoblastoma binding protein 6 isoform 3 antibody; Retinoblastoma binding Q protein 1 antibody; Retinoblastoma-binding protein 6 antibody; Retinoblastoma-binding Q protein 1 antibody; SNAMA antibody; SNAMA, Drosophila, homolog of antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q7Z6E9

Immunogen:Recombinant Human E3 ubiquitin-protein ligase RBBP6 protein (51-97AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RBBP6

Research Areas:Cancer; Cell biology