Rat Vascuoar Endothelial Cell Growth Factor Receptor 3, VEGFR-3 ELISA Kit

SKU: E1461Ra

Size:96 Tests-1 Kit

Background:Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473' (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:FLT4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:1.41ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Vascuoar Endothelial Cell Growth Factor Receptor 3

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q91ZT1

MASS(Da):153,317

GeneID:114110

Synonyms:FLT 4;FLT4;FLT-4;Fms-like tyrosine kinase 4;Tyrosine-protein kinase receptor FLT4;Vascular endothelial growth factor receptor 3;VEGFR-3

Gene names:FLT4

Standard solution:960ng/L