Rat Transient Receptor Potential Cation Channel Subfamily V Member 4, TRPV4 ELISA Kit

SKU: E2291Ra

Size:96 Tests-1 Kit

Background:Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by heat, low pH, citrate and phorbol esters (By similarity). Increase of intracellular Ca2+ potentiates currents (By similarity). Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca2+ in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:TRPV4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:7.19ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transient receptor potential cation Channel subfamily V member 4

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9ERZ8

MASS(Da):98,010

GeneID:66026

Synonyms:Osm-9-like TRP Channel 4;Otrpc4;Transient receptor potential cation Channel subfamily V member 4;TRPV4;Vanilloid receptor-related osmotically-activated Channel;Vroac;VR-OAC

Gene names:Trpv4

Standard solution:3200ng/L