Rat Thioredoxin-interacting Protein, TXNIP ELISA Kit

SKU: E2277Ra

Size:96 Tests-1 Kit

Background:May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:TXNIP

Reactivity:Rat

Assay type:Sandwich

Sensitivity:9.95ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Thioredoxin-interacting protein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5M7W1

MASS(Da):44,018

GeneID:117514

Synonyms:Thioredoxin-interacting protein;TXNIP;Vdup1;Vitamin D3 up-regulated protein 1

Gene names:Txnip

Standard solution:6400ng/L