Rat S100 Calcium Binding Protein A4, S100A4 ELISA Kit

SKU: E1341Ra

Size:96 Tests-1 Kit

Background:Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:S100A4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.63ng/L

Detection range:10-4000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:S100 Calcium Binding Protein A4

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P05942

MASS(Da):11,776

GeneID:24615

Synonyms:Metastasin;Nerve growth factor-induced protein 42A;P9K;Placental calcium-binding protein;Protein S100-A4;S100 calcium-binding protein A4;S100A4

Gene names:S100A4

Standard solution:4800ng/L