Rat Runt-related Transcription Factor 2, RUNX2 ELISA Kit

SKU: E2244Ra

Size:96 Tests-1 Kit

Background:Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Research_area:Others

Applications:ELISA

Target_protein:RUNX2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.46ng/mL

Detection range:1-400ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Runt-related transcription factor 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z2J9

MASS(Da):24,247

GeneID:367218

Synonyms:Cbfa1;CBF-alpha-1;Core-binding factor subunit alpha-1;Fragments;OSF-2;Osteoblast-specific transcription factor 2;Runt-related transcription factor 2;RUNX2

Gene names:Runx2

Standard solution:480ng/mL