Rat Neuropilin-1, NRP1 ELISA Kit

SKU: E2469Ra

Size:96 Tests-1 Kit

Background:Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:NRP1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neuropilin-1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9QWJ9

MASS(Da):103,082

GeneID:246331

Synonyms:CD antigen CD304;Neuropilin-1;Nrp;NRP1;Vascular endothelial cell growth factor 165 receptor

Gene names:Nrp1

Standard solution:12.8ng/ml