Rat Mothers Against Decapentaplegic Homolog 2, SMAD2 ELISA Kit

SKU: E1258Ra

Size:96 Tests-1 Kit

Background:Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:SMAD2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.11ng/L

Detection range:10-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Mothers Against Decapentaplegic Homolog 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O70436

MASS(Da):52,239

GeneID:29357

Synonyms:MAD homolog 2;Mad-related protein 2;Mothers against decapentaplegic homolog 2;Mothers against DPP homolog 2;SMAD 2;SMAD family member 2;SMAD2

Gene names:SMAD2

Standard solution:3200ng/L