Rat Cyclin-dependent Kinase 4, CDK-4 ELISA Kit

SKU: E1303Ra

Size:96 Tests-1 Kit

Background:Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:CDK4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.043ng/ml

Detection range:0.1-50ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cyclin-Dependent Kinase 4

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35426

MASS(Da):33,799

GeneID:94201

Synonyms:CDK 4;CDK4;Cell division protein kinase 4;Cyclin-dependent kinase 4;PSK-J3

Gene names:CDK4

Standard solution:56ng/ml