Rat Caspase-6, CASP6 ELISA Kit

SKU: E1454Ra

Size:96 Tests-1 Kit

Background:Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity. During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (By similarity).

Research_area:Neuroscience; Cell Biology; Cancer; Metabolism

Applications:ELISA

Target_protein:CASP6

Reactivity:Rat

Assay type:Sandwich

Sensitivity:4.93ng/L

Detection range:10-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase-6

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35397

MASS(Da):31,556

GeneID:83584

Synonyms:Apoptotic protease Mch-2;CASP6;CASP-6;Caspase-6;Caspase-6 subunit p11];Caspase-6 subunit p18;Mch2

Gene names:Casp6

Standard solution:3200ng/L