RAF1 Monoclonal Antibody

SKU: BT-MCA3221

Size:100μL

Background:This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Research_area:Signal Transduction

Target_protein:RAF1

applications:WB, IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4G4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:RAF1

Immunogen:Purified recombinant fragment of human RAF1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):73kDa

UniProt accession:P04049

Synonyms:NS5, CRAF, Raf-1, c-Raf

GeneID:5894