PVR Antibody - Cat. #: CSB-PA019093ESR2HU

SKU: CSB-PA019093ESR2HU

Size :50ul

Clone Number:

Aliases:CD155 antibody; CD155 antigen antibody; FLJ25946 antibody; HVED antibody; mE4 antibody; NECL 5 antibody; Necl-5 antibody; Necl5 antibody; Nectin like 5 antibody; Nectin like protein 5 antibody; Nectin-like protein 5 antibody; Ortholog of mouse Tage4 antibody; Poliovirus receptor antibody; PVR antibody; PVR_HUMAN antibody; PVS antibody; Taa1 antibody; Tage 4 antibody; TAGE4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P15151

Immunogen:Recombinant Human Poliovirus receptor protein (220-345AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PVR

Research Areas:Microbiology