Purified Anti-Human CD192 Antibody[K036C2]

SKU: GBS-F1385A

Size:1mg

Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Flow Cytometry Antibodies

Abbreviation:CD192

Target Synonym:CKR;CMKBR;CC-CKR;CCR;CCR2;CC-CKR-2;CCR-2;CCR2A;CCR2B;CD192;CKR2;CKR2A;CKR2B;CMKBR2;MCP-1-R;FLJ78302;C C chemokine receptor type 2;C C CKR 2;CC chemokine receptor type 2;C-C chemokine receptor type 2;CC CKR 2;C-C CKR-2;CCCKR2;CCR 2;CCR1L;CCR5L;CD192 antigen;Chemokine C C motif receptor 2;Chemokine CC Motif Receptor 2;CKR 2;cluster of differentiation 192;MCP 1 R;MCP1 RECEPTOR;MCP1R;MCP-1-R;Monocyte chemoattractant protein 1 receptor;Monocyte Chemotactic Protein 1 Receptor

Research Areas:Immunology;Microbiology;Signal Transduction;Cancer;Cardiovascular

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:FCM

Usage:

Isotype:Mouse IgG2a, κ

Clonality:Monoclonal

Clone NO.:K036C2

UNIProt ID:P41597

Background:CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.

Concentration: ≥ 1 mg/mL

Control catalog number:

Immunogen:Recombinant Human CD192 protein

Buffer:Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Purification method:>98%, Protein A/G purified

Dilution:FCM 2 μg/mL(0.5×10⁶-1×10⁶ cells)

GeneID:729230