PTPN11 antibody , Cat. # FNab06932

SKU: FNab06932

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Immunogen:protein tyrosine phosphatase, non-receptor type 11

Synonyms:PTP2C, SHPTP2

Observed MW:71KDa

Uniprot ID:Q06124

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

Gene ID:5781

Research Area:Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology