PPM1A Monoclonal Antibody

SKU: BT-MCA2944

Size:100μL

Background:The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Research_area:Epigenetics and nuclear signaling, Signal transduction

Target_protein:PPM1A

applications:WB, FCM

Reactivity:Human, Monkey

Clonality:Monoclonal

Clone ID:7F12H6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PPM1A

Immunogen:Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):42.4kDa

UniProt accession:P20265

Synonyms:PP2CA, PP2Calpha, PP2C-ALPHA

GeneID:5494