POLR3C Antibody - Cat. #: CSB-PA097153

SKU: CSB-PA097153

Size :100ul

Clone Number:

Aliases:DNA directed III 62 kDa polypeptide antibody; DNA-directed RNA polymerase III subunit C antibody; DNA-directed RNA polymerase III subunit rpc3 antibody; POLR3C antibody; Polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody; RNA polymerase C subunit 3 antibody; RNA polymerase III 62 kDa subunit antibody; RNA polymerase III C62 subunit antibody; RNA polymerase III subunit C3 antibody; RPC3 antibody; RPC3_HUMAN antibody; RPC62 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BUI4

Immunogen:Synthesized peptide derived from internal of Human RPC3.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Wang Z., Genes Dev. 11:1315-1326(1997).
Kuwana M., Arthritis Rheum. 46:2742-2747(2002).
Hsieh Y.-J., Mol. Cell. Biol. 19:7697-7704(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:POLR3C

Research Areas:Epigenetics and Nuclear Signaling