PIAS3 Antibody - Cat. #: CSB-PA283252

SKU: CSB-PA283252

Size :100ul

Clone Number:

Aliases:E3 SUMO protein ligase PIAS 3 antibody; E3 SUMO protein ligase PIAS3 antibody; E3 SUMO-protein ligase PIAS3 antibody; FLJ14651 antibody; OTTHUMP00000015586 antibody; OTTHUMP00000015587 antibody; PIAS 3 antibody; Pias3 antibody; PIAS3 protein antibody; PIAS3_HUMAN antibody; Protein inhibitor of activated STAT 3 antibody; Protein inhibitor of activated STAT protein 3 antibody; Protein inhibitor of activated STAT3 antibody; Zinc finger MIZ type containing 5 antibody; ZMIZ 5 antibody; ZMIZ5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y6X2

Immunogen:Synthesized peptide derived from Internal of Human PIAS3.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.

Jiang-Hong Man, Nucleic Acids Res., Nov 2006; 34: 5552 - 5566.
Amir Sonnenblick, Mol. Cell. Biol., Dec 2004; 24: 10584 - 10592.
Jianyin Long, PNAS, Jan 2004; 101: 99.
Hyun Duk Jang, J. Biol. Chem., Jun 2004; 279: 24873 - 24880.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PIAS3

Research Areas:Epigenetics and Nuclear Signaling;Cell biology