Phospho-TNK2 (Tyr284) Antibody - Cat. #: CSB-PA309705

SKU: CSB-PA309705

Size :100ul

Clone Number:

Aliases:Acetate kinase 1 antibody; Acetokinase 1 antibody; ACK 1 antibody; ACK antibody; ACK-1 antibody; ACK1 antibody; ACK1_HUMAN antibody; Activated Cdc42 associated kinase 1 antibody; Activated CDC42 kinase 1 antibody; Activated p21cdc42Hs kinase antibody; FLJ44758 antibody; FLJ45547 antibody; p21cdc42Hs antibody; TNK 2 antibody; TNK2 antibody; Tyrosine kinase non receptor 2 antibody; Tyrosine kinase non receptor protein 2 antibody; Tyrosine kinase non-receptor protein 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q07912

Immunogen:Peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y(p)-V-M) derived from Human ACK1.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Background:

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes.

Manser E., Nature 363:364-367(1993).
Ota T., Nat. Genet. 36:40-45(2004).
Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TNK2

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction