Phospho-STAT2 (Tyr690) Antibody - Cat. #: CSB-PA058079

SKU: CSB-PA058079

Size :100ul

Clone Number:

Aliases:Homo sapiens interferon alpha induced transcriptional activator antibody; interferon alpha induced transcriptional activator antibody; ISGF 3 antibody; ISGF3 antibody; MGC59816 antibody; P113 antibody; signal transducer and activator of transcription 2 113kD antibody; Signal transducer and activator of transcription 2 antibody; STAT113 antibody; Stat2 antibody; STAT2_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P52630

Immunogen:Peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y(p)-L-K)derived from Human Stat2

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Fu X.Y,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992)
Yan R,et al. Nucleic Acids Res. 23:459-463(1995)
Fu X.Y.Cell 70:323-335(1992)
Sugiyama T,et al.FEBS Lett. 381:191-194(1996)

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:STAT2

Research Areas:Epigenetics and Nuclear Signaling;Signal transduction