Phospho-GRIN1 (Ser890) Antibody - Cat. #: CSB-PA239875

SKU: CSB-PA239875

Size :100ul

Clone Number:

Aliases:GluN1 antibody; Glutamate [NMDA] receptor subunit zeta-1 antibody; Glutamate receptor ionotropic N methyl D aspartate 1 antibody; Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1 antibody; glutamate receptor ionotropic, NMDA 1 antibody; Grin1 antibody; MRD8 antibody; N methyl D aspartate receptor antibody; N methyl D aspartate receptor channel subunit zeta 1 antibody; N methyl D aspartate receptor subunit NR1 antibody; N-methyl-D-aspartate receptor subunit NR1 antibody; NMD-R1 antibody; NMDA 1 antibody; NMDA R1 antibody; NMDA receptor 1 antibody; NMDA1 antibody; NMDAR antibody; NMDZ1_HUMAN antibody; NR1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q05586

Immunogen:Peptide sequence around phosphorylation site of serine890(A-S-S(p)-F-K) derived from Human NMDAR1 .

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Xu M, Smothers CT, Woodward JJ (2011) Alcohol 45, 373-80. Kong M, Ba M, Song L, Liu Z (2009)Neurochem Res 34, 1513-21 . Jackson MF, et al. (2006)J Neurochem 96, 1509-18.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GRIN1

Research Areas:Neuroscience