Phospho-CHUK/IKBKB (Ser180/181) Antibody - Cat. #: CSB-PA586587

SKU: CSB-PA586587

Size :100ul

Clone Number:

Aliases:chuk antibody; CHUK1 antibody; Conserved Helix Loop Helix Ubiquitous Kinase antibody; Conserved helix loop ubiquitous kinase antibody; Conserved helix-loop-helix ubiquitous kinase antibody; I Kappa B Kinase 1 antibody; I Kappa B Kinase Alpha antibody; I-kappa-B kinase 1 antibody; I-kappa-B kinase alpha antibody; IkappaB kinase antibody; IkB kinase alpha subunit antibody; IkBKA antibody; IKK 1 antibody; IKK A antibody; IKK a kinase antibody; IKK-A antibody; IKK-alpha antibody; IKK1 antibody; IKKA antibody; IKKA_HUMAN antibody; Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody; Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody; Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody; NFKBIKA antibody; Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody; Nuclear factor NF kappa B inhibitor kinase alpha antibody; Nuclear factor NF-kappa-B inhibitor kinase alpha antibody; Nuclear factor NFkappaB inhibitor kinase alpha antibody; Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody; TCF-16 antibody; TCF16 antibody; Transcription factor 16 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15111

Immunogen:Peptide sequence around phosphorylation site of serine 180/181 (C-T-S(p)-F-V) derived from Human IKK- alpha/ beta.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

Hafeez BB, et al. (2008) Cancer Res 68, 8564-72
Cahill CM, Rogers JT (2008) J Biol Chem 283, 25900-12
Encinas M, et al. (2008)Cell Death Differ 15, 1510-21

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CHUK/IKBKB

Research Areas:Cancer?Cardiovascular?Cell biology;Immunology;Signal transduction