Phospho-CBL (Tyr700) Antibody - Cat. #: CSB-PA205538

SKU: CSB-PA205538

Size :100ul

Clone Number:

Aliases:4732447J05Rik antibody; C CBL antibody; Cas Br M (murine) ecotropic retroviral transforming sequence antibody; Casitas B lineage lymphoma proto oncogene antibody; Casitas B-lineage lymphoma proto-oncogene antibody; CBL 2 antibody; cbl antibody; CBL_HUMAN antibody; CBL2 antibody; E3 ubiquitin protein ligase CBL antibody; E3 ubiquitin-protein ligase CBL antibody; Oncogene CBL2 antibody; Proto oncogene c CBL antibody; Proto-oncogene c-CBL antibody; RGD1561386 antibody; RING finger protein 55 antibody; RNF55 antibody; Signal transduction protein CBL antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P22681

Immunogen:Peptide sequence around phosphorylation site of tyrosine 770 (T-E-Y(p)-M-T) derived from Human c-Cbl.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Background:Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

Blake, T.J. et al. (1991) Oncogene 6, 653-657.
Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.
Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.
Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CBL

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Signal transduction