Phospho-Amyloid-Beta (T743) Polyclonal Antibody

SKU: BT-PHS00855

Size:100μL

Background:APP encodes a cell surface receptor and transmembrane precursor protein (amyloid beta precursor protein) that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in APP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for APP.

Research_area:Neuroscience; Signal Transduction

Target_protein:APP

applications:WB, IHC-p, IF, ELISA

Reactivity:Human, mouse, rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Phospho-Amyloid-beta (T743) Antibody

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):86943

UniProt accession:Human: P05067; Mouse: P12023; Rat: P08592

Synonyms:amyloid beta (A4) protein; ABETA; ABPP; APP; APPI; amyloid beta A4; beta amyloid; Amyloid-Beta; Amyloid Beta; AB

GeneID:Human: 351; Mouse: 11820; Rat: 54226