Phospho-ALK (Tyr1096) Antibody - Cat. #: CSB-PA116393

SKU: CSB-PA116393

Size :100ul

Clone Number:

Aliases:Alk antibody; ALK tyrosine kinase receptor antibody; ALK/EML4 fusion gene; included antibody; ALK/NPM1 fusion gene; included antibody; ALK_HUMAN antibody; anaplastic lymphoma kinase (Ki-1) antibody; Anaplastic lymphoma kinase antibody; Anaplastic lymphoma kinase Ki1 antibody; anaplastic lymphoma receptor tyrosine kinase antibody; CD 246 antibody; CD246 antibody; CD246 antigen antibody; EC 2.7.10.1 antibody; Ki 1 antibody; Ki1 antibody; mutant anaplastic lymphoma kinase antibody; NBLST 3 antibody; NBLST3 antibody; Tcrz antibody; TFG/ALK antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UM73

Immunogen:Peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y(p)-C-F) derived from Human ALK.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, IHC; IHC:1:50-1:100

Background:

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain.

Morris S.W., Oncogene 14:2175-2188(1997).
Morris S.W., Oncogene 15:2883-2883(1997).
Iwahara T., Oncogene 14:439-449(1997).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ALK

Research Areas:Neuroscience?Cancer;Tags & Cell Markers