PHLDA3 Antibody - Cat. #: CSB-PA185414

SKU: CSB-PA185414

Size :100ul

Clone Number:

Aliases:PHLA3_HUMAN antibody; PHLDA 3 antibody; phlda3 antibody; Pleckstrin homology like domain family A member 2 antibody; Pleckstrin homology like domain family A member 3 antibody; Pleckstrin homology-like domain family A member 3 antibody; TDAG51/Ipl homolog 1 antibody; TDAG51/Ipl homologue 1 antibody; TIH 1 antibody; TIH1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y5J5

Immunogen:Synthesized peptide derived from internal of Human PHLDA3.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

Frank D., Mamm. Genome 10:1150-1159(1999).
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PHLDA3

Research Areas:Cell biology