PEK/PERK Polyclonal Antibody

SKU: BT-AP12928

Size:100μL

Background:The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Research_area:Epigenetics and nuclear signaling; Metabolism

Target_protein:EIF2AK3

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Eukaryotic translation initiation factor 2-alpha kinase 3

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q9NZJ5; Mouse: Q9Z2B5; Rat: Q9Z1Z1

Synonyms:Eukaryotic translation initiation factor 2-alpha kinase 3 ;EC 2.7.11.1;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK; Eukaryotic translation initiation factor 2-alpha kinase 3; EC 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK

GeneID:Human: 9451; Mouse: 0; Rat: 29702