PDK4 Polyclonal Antibody

SKU: AN006800L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:PDK4

Target Synonym:PDK;PDHK;Pyruvate dehydrogenase lipoamide kinase isozyme;PDK4PDHK;PDK4;FLJ40832;mitochondrial;Pyruvate dehydrogenase lipoamide kinase isozyme 4;PDK4PDHK4;PDHK4;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial;Pyruvate dehydrogenase kinase 4;Pyruvate dehydrogenase kinase isoenzyme 4;Pyruvate dehydrogenase kinase isoform 4;Pyruvate dehydrogenase kinase isozyme 4;Pyruvate dehydrogenase kinase isozyme 4 mitochondrial

Research Areas:Signal Transduction; Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q16654

Accession:

Background:Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

Concentration:1 mg/mL

Immunogen:Recombinant Human PDK4 protein expressed by E.coli

Buffer:PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:46 kDa

ObservedMW:50-55 kDa