PAX5 Antibody - Cat. #: CSB-PA295467

SKU: CSB-PA295467

Size :50ul

Clone Number:

Aliases:B cell lineage specific activator antibody; B cell lineage specific activator protein antibody; B cell specific activator protein antibody; B cell specific transcription factor antibody; B-cell-specific transcription factor antibody; BSAP antibody; EBB-1 antibody; KLP antibody; Paired box 5 antibody; Paired box gene 5 (B cell lineage specific activator protein) antibody; Paired box gene 5 (B cell lineage specific activator) antibody; Paired box gene 5 antibody; Paired box homeotic gene 5 antibody; Paired box protein Pax 5 antibody; Paired box protein Pax-5 antibody; Paired domain gene 5 antibody; PAX 5 antibody; PAX5 antibody; PAX5_HUMAN antibody; Transcription factor PAX 5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q02548

Immunogen:Synthetic peptide of Human PAX5

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

Background:This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PAX5

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience