p21 Polyclonal Antibody

SKU: E-AB-70068

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:p21

Target Synonym:CAP20;CDK-interacting protein 1;CDKI;CDKN1;Cdkn1a;CDN1A;CIP1;Cyclin Dependent Kinase Inhibitor 1A;Cyclin-dependent kinase inhibitor 1;Cyclin-dependent kinase inhibitor 1A (P21);Cyclin-dependent kinase inhibitor 1A (p21;Cip1);DNA Synthesis Inhibitor;MDA-6;MDA6;Melanoma differentiation-associated protein 6;Melanoma differentiation-associated protein;p21;P21 protein;p21CIP1;p21Cip1/Waf1;p21WAF;PIC1;SDI1;SLC12A9;WAF1;Wild type p53 activated fragment 1 (WAF1);Wild type p53 activated fragment 1;Wildtype p53-activated fragment 1

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P38936,P39689

Accession:

Background:CDKN1A (p21,CIP1,WAF1),a cyclin-dependent kinase inhibitor,is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA),and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases,which thus leads to a dramatic activation of CDK2,and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.

Concentration:0.7 mg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to Mouse P21

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:200-1:800

Calculated MW:

ObservedMW: