NR3C1 Monoclonal Antibody

SKU: BT-MCA2634

Size:100μL

Background:The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.

Research_area:Signal Transduction

Target_protein:NR3C1

applications:WB, IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:6E6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:NR3C1

Immunogen:Purified recombinant fragment of human NR3C1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):86kDa

UniProt accession:P04150

Synonyms:GR, GCR, GRL, GCCR, NR3C1

GeneID:2908