NPC2 Antibody, FITC conjugated - Cat. #: CSB-PA015976LC01HU

SKU: CSB-PA015976LC01HU

Size :50ug

Clone Number:

Aliases:EDDM1 antibody; Epididymal protein 1 antibody; Epididymal secretory protein antibody; Epididymal secretory protein E1 antibody; hE1 antibody; Human epididymis-specific protein 1 antibody; Niemann-Pick disease type C2 antibody; Niemann-Pick disease type C2 protein antibody; NPC intracellular cholesterol transporter 2 antibody; NPC2 antibody; NPC2_HUMAN antibody; Tissue specific secretory protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P61916

Immunogen:Recombinant Human NPC intracellular cholesterol transporter 2 protein (20-151AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \\\'tag team duo\\\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NPC2

Research Areas:Neuroscience; Cardiovascular; Metabolism; Signal transduction