NFkB p100 / p52 Polyclonal Antibody

SKU: E-AB-65807

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:NFkB p100 / p52

Target Synonym:CVID10;H2TF1;LYT-10;LYT10;NF-kB2;p100;p49/p100;p52

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IF

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q00653

Accession:

Background:This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

Concentration:1mg/mL

Immunogen:Recombinant fusion protein of human NFkB p100 / p52 (NP_002493.3).

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification method:Affinity purification

Dilution:WB 1:500-1:2000;IF 1:50-1:200

Calculated MW:47kDa/96kDa

ObservedMW:125kDa