NFE2 Polyclonal Antibody

SKU: BT-AP09118

Size:100μL

Background:Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production: globin synthesis| heme synthesis| and the procurement of iron.|Belongs to the bZIP family.|Belongs to the bZIP family. CNC subfamily.|Contains 1 bZIP domain.|subunit:Interacts with MLL2; leading to activate transcription of the beta-globin locus (By similarity). Heterodimer of p45 NF-E2 and p18 NF-E2. Forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis.|tissue specificity:Expressed in hematopoietic cells and also in colon and testis.|

Research_area:Epigenetics and nuclear signaling

Target_protein:NFE2

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Transcription factor NF-E2 45 kDa subunit

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q16621; Mouse: Q07279; Rat: Q6AYT2

Synonyms:Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2;Nuclear factor; erythroid-derived 2 45 kDa subunit;p45 NF-E2)

GeneID:Human: 4778