NDP Antibody - Cat. #: CSB-PA015609LA01HU

SKU: CSB-PA015609LA01HU

Size :50ug

Clone Number:

Aliases:EVR2 antibody; Exudative vitreoretinopathy 2 (X linked) antibody; FEVR antibody; ND antibody; NDP antibody; NDP_HUMAN antibody; Norrie disease (pseudoglioma) antibody; Norrie disease protein antibody; Norrin antibody; Norrin precursor antibody; X linked exudative vitreoretinopathy 2 protein antibody; X-linked exudative vitreoretinopathy 2 protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q00604

Immunogen:Recombinant Human Norrin protein (25-133AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NDP

Research Areas:Neuroscience; Stem cells