MYC Monoclonal Antibody

SKU: BT-MCA2286

Size:100μL

Background:The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (provided by RefSeq).

Research_area:Epigenetics and Nuclear Signaling

Target_protein:MYC

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:7E10

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MYC

Immunogen:Purified recombinant fragment of human MYC expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):49kDa

UniProt accession:P01106

Synonyms:MRTL, c-Myc, bHLHe39

GeneID:4609