Mouse Tyrosine-protein Phosphatase Non-receptor Type Substrate 1, SIRPA ELISA Kit

SKU: E2549Mo

Size:96 Tests-1 Kit

Background:Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:SIRPA

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.84ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P97797

MASS(Da):56,414

GeneID:19261

Synonyms:Bit;Brain Ig-like molecule with tyrosine-based activation motifs;CD antigen CD172a;CD172 antigen-like family member A;Inhibitory receptor SHPS-1;mSIRP-alpha1;MyD-1 antigen;p84;SHP substrate 1;SHPS-1;Signal-regulatory protein alpha-1;SIRPA;Sirp-alpha-1;Tyrosine-protein phosphatase non-receptor type substrate 1

Gene names:SIRPA

Standard solution:4800ng/L