Mouse Tyrosine-protein kinase receptor UFO,AXL ELISA KIT

SKU: E1398Mo

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:18083102, ECO:0000269|PubMed:20363878}.

Research_area:

Applications:ELISA

Target_protein:Axl

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:11.61ng/L

Detection range:25-1600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine-protein kinase receptor UFO

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q00993

MASS(Da):98191

GeneID:26362

Synonyms:Axl Ark Ufo

Gene names:Axl

Standard solution:3200ng/L