Mouse Twist-related Protein 1, TWIST1 ELISA Kit

SKU: E2547Mo

Size:96 Tests-1 Kit

Background:Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.

Research_area:Neuroscience

Applications:ELISA

Target_protein:TWIST1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:5.63ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Twist-related protein 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P26687

MASS(Da):21,198

GeneID:22160

Synonyms:bHLHa;bHLHa38;M-Twi;M-Twist;pd;Pde;pdt;Pluri;Ska;Ska;Twist;TWIST1;Twist-related protein 1

Gene names:Twist1

Standard solution:2400ng/L