Mouse Sterol Regulatory Element-binding Protein 2, SREBF2 ELISA Kit

SKU: E2490Mo

Size:96 Tests-1 Kit

Background:Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:9616204, PubMed:16100574). Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:9616204). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:9616204).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:SREBF2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.21ng/L

Detection range:2-600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sterol regulatory element-binding protein 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q3U1N2

MASS(Da):122,911

GeneID:20788

Synonyms:AI608257;bHLHd2;lo;lop13;nu;nuc;Processed sterol regulatory element-binding protein 2;SRE;SREB;SREBF2;SREBP;SREBP2;SREBP-2;SREBP2gc;Sterol regulatory element-binding protein 2;Sterol regulatory element-binding transcription factor 2;Transcription factor SREBF2]

Gene names:Srebf2

Standard solution:640ng/L