Mouse Serine Protease HTRA1, HTRA1 ELISA Kit

SKU: E2457Mo

Size:96 Tests-1 Kit

Background:Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Research_area:Others

Applications:ELISA

Target_protein:HTRA1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:14.75ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Serine protease HTRA1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9R118

MASS(Da):51,214

GeneID:56213

Synonyms:AI429470;High-temperature requirement A serine peptidase 1;Htr;HTRA;HTRA1;L5;L56;Pr;RS;RSPP11;Serine protease 11;Serine protease HTRA1

Gene names:Htra1

Standard solution:9600ng/L